PROTAC CRBN Degrader-1
PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader that achieves a selective degradation of CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other[1]. (Blue: VHL ligand (S, R, S) -AHPC (HY-125845) ; Pink: CRBN ligand Pomalidomide-C2-NH2 (HY-128846) ; Black: Linker (HY-128847) )
Product Specifications
CAS Number
[2358775-70-7]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-crbn-degrader-1.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=CC=C3)=O
Molecular Formula
C53H72N8O13S
Molecular Weight
1061.25
References & Citations
[1]Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27 (12) :2466-2479.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; von Hippel-Lindau (VHL)
Available Sizes
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