Ofloxacin

Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV) .

Product Specifications

CAS Number

[82419-36-1]

Product Name Alternative

Hoe-280

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H334, H335, H341, H361

Target

Antibiotic; Bacterial; Endogenous Metabolite; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Ofloxacin.html

Purity

99.95

Solubility

DMSO : ≥ 4 mg/mL

Smiles

O=C(C(C1=O)=CN2C(C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O

Molecular Formula

C18H20FN3O4

Molecular Weight

361.37

Precautions

H315, H317, H319, H334, H335, H341, H361

References & Citations

[1]Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42 (5) :825-76.|[2]Smith JT, et al. Ofloxacin, a bactericidal antibacterial. Chemotherapy. 1991;37 Suppl 1:2-13.|[3]Olcay E, et al. Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats. J Toxicol Sci. 2011 Jun;36 (3) :339-45.|[4]S Ikeda , et al. Antiviral activity and inhibition of topoisomerase by ofloxacin, a new quinolone derivative. Antiviral Res. 1987 Oct;8 (3) :103-13.