Murepavadin (TFA)
Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance[1][2].
Product Specifications
Product Name Alternative
POL7080 (TFA)
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/murepavadin-tfa.html
Purity
99.53
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@@](CCC1)([H])C(N2C(CCC2)([H])C(N[C@@](C(N3)=O)([H])[C@H](O)C)=O)=O)=O)CO)=O)C)=O)CCN)=O)CCN)=O)CC4=CNC5=CC=CC=C45)=O)CCN)=O)CCN)=O)CCCN)=O)CCN)=O)([H])[C@@H](C)CC)[C@@H]3CC6=CNC7=CC=CC=C67.O=C(O)C(F)(F)F
Molecular Formula
C73H112N22O16.C2HF3O2
Molecular Weight
1667.83
References & Citations
[1]Matteo Bassetti, et al. New antibiotics for ventilator-associated pneumonia. Curr Opin Infect Dis. 2018 Jan 13.|[2]Ignacio Martin-Loeches, et al. Murepavadin: a new antibiotic class in the pipeline. Expert Rev Anti Infect Ther. 2018 Apr;16 (4) :259-268.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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