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Ulotaront (hydrochloride)

SEP-363856 (SEP-856) hydrochloride, an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride has the potential for the study of schizophrenia[1].

Product Specifications

CAS Number

1310422-41-3

Product Name Alternative

SEP-363856 (hydrochloride) ; SEP-856 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H319, H336, H373

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sep-363856-hydrochloride.html

Purity

99.89

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CNC[C@H]1C2=C(C=CS2)CCO1.Cl

Molecular Formula

C9H14ClNOS

Molecular Weight

219.73

Precautions

H302, H319, H336, H373

References & Citations

[1]Dedic N, et al. SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action. J Pharmacol Exp Ther. 2019 Oct;371 (1) :1-14.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

5-HT1 Receptor; mLAG-3; MUC3; α-1 microglobulin

Citation 01

Adv Sci (Weinh) . 2025 Oct 24:e02079.|Cell. 2023 Nov 22;186 (24) :5347-5362.e24.|Drug Dev Res. 2024 Jun;85 (4) :e22225.|Mol Pharmacol. 2025 Jul 28;107 (9) :100064.|Nature. 2024 Jun;630 (8015) :237-246.|Synapse. 2025 Mar;79 (2) :e70011.|World J Biol Psychiatry. 2024 Nov 29:1-18.|Front Pharmacol. 2023 Apr 21:14:1161964.|J Med Chem. 2025 Apr 10;68 (7) :7082-7105.|Nature. 2023 Dec;624 (7992) :672-681.

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