Crystallin-αC rabbit pAb
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
26353
UniProt
Q9UJY1
Cellular Locus
Cytoplasm. Nucleus. Translocates to nuclear foci during heat shock.
Host
Rabbit
Species Reactivity
Human
Reactivity
Human
Immunogen
Recombinant Protein of Crystallin-αC
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Dilution
WB: 1:500-1000
Molecular Weight
22kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20776-1.pdf
Observed Molecular Weight
22 kD
Subcellular Location
Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
Other Product Names
Gene ID (Human)
26353
SwissProt (Human)
Q9UJY1
Available Sizes
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