MY-673
Product Specifications
UNSPSC Description
MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. MY-673 inhibits the ERK signaling pathway, which in turn affects SMAD4 protein expression levels in the TGF-β/SMAD pathway. MY-673 inhibited cell proliferation, migration and induced apoptosis in vivo and in vitro[1].
Target Antigen
Apoptosis; ERK; Microtubule/Tubulin; TGF-beta/Smad
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;MAPK/ERK Pathway;Stem Cell/Wnt;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/my-673.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1OC2=CC=CC=C2C(N3C4=CC=C(OC)C=C4NC(C3)=O)=C1
Molecular Weight
322.31
References & Citations
[1]Song J, et al. Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities. Bioorg Chem. 2023 Aug;137:106580.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149414/MY-673-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149414/MY-673-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2944459-96-3
Available Sizes
Curated Selection
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