Landipirdine
Landipirdine (RO5025181; SYN120) is an orally active 5-HT6 and 5-HT2A receptors antagonist. Landipirdine can be used for the study of Parkinson disease[1].
Product Specifications
CAS Number
[1000308-25-7]
Product Name Alternative
RO5025181; SYN120
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/landipirdine.html
Purity
99.80
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(NC[C@H]1C2=CC=C(S(=O)(C3=CC(F)=CC=C3)=O)C=C2CCC1)=O
Molecular Formula
C18H19FN2O3S
Molecular Weight
362.42
References & Citations
[1]Fernandez HH, et al. Safety, tolerability, and preliminary efficacy of SYN120, a dual 5-HT6/5-HT2A antagonist, for the treatment of Parkinson disease dementia: A randomized, controlled, proof-of-concept trial. Parkinsonism Relat Disord. 2023 Sep;114:105511.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor;5-HT6 Receptor
Available Sizes
Curated Selection
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