Tumulosic acid
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM) . Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].
Product Specifications
CAS Number
508-24-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tumulosic-acid.html
Purity
98.66
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@](C(CC[C@](C(C)1C)([H])[C@@]2(CC[C@@H]1O)C)=C2CC3)(C[C@H]4O)[C@]3([C@@]4([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
Molecular Formula
C31H50O4
Molecular Weight
486.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22 (11) :1829. Published 2017 Oct 27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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