Tumulosic acid

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM) . Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

Product Specifications

CAS Number

[508-24-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tumulosic-acid.html

Purity

98.66

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@](C(CC[C@](C(C)1C)([H])[C@@]2(CC[C@@H]1O)C)=C2CC3)(C[C@H]4O)[C@]3([C@@]4([H])[C@H](C(O)=O)CCC(C(C)C)=C)C

Molecular Formula

C31H50O4

Molecular Weight

486.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22 (11) :1829. Published 2017 Oct 27.