Dihydrocapsaicin

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].

Product Specifications

CAS Number

[19408-84-5]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Akt; Apoptosis; Bcl-2 Family; Caspase; PI3K; Reactive Oxygen Species (ROS) ; TRP Channel

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dihydrocapsaicin.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)CCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C18H29NO3

Molecular Weight

307.43

Precautions

H301, H315, H319, H335

References & Citations

[1]Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55 (4) :1018-25.|[2]Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.|[3]Adams MJ, et al. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009 Dec;124 (6) :721-3.