PF-06761281
PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 μM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].
Product Specifications
CAS Number
[1854061-19-0]
UNSPSC
12352005
Hazard Statement
H301
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-06761281.html
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O
Molecular Formula
C13H17NO6
Molecular Weight
283.28
Precautions
H301
References & Citations
[1]Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59 (3) :1165-75.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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