PF-06761281

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 μM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].

Product Specifications

CAS Number

[1854061-19-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pf-06761281.html

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O

Molecular Formula

C13H17NO6

Molecular Weight

283.28

Precautions

H301

References & Citations

[1]Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59 (3) :1165-75.