DKFZ-748

DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].

Product Specifications

CAS Number

[2490709-68-5]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dkfz-748.html

Purity

98.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCN(CCCC(NO)=O)C)C1=C2C=CC=CC2=CC=C1

Molecular Formula

C18H23N3O3

Molecular Weight

329.39

References & Citations

[1]Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144 (41) :18861-18875.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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