DKFZ-748
DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].
Product Specifications
CAS Number
[2490709-68-5]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dkfz-748.html
Purity
98.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCN(CCCC(NO)=O)C)C1=C2C=CC=CC2=CC=C1
Molecular Formula
C18H23N3O3
Molecular Weight
329.39
References & Citations
[1]Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144 (41) :18861-18875.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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