STF-083010
Product Specifications
UNSPSC Description
STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
Target Antigen
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/STF-083010.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CS1)(/N=C/C2=C3C=CC=CC3=CC=C2O)=O
Molecular Weight
317.38
References & Citations
[1]Papandreou I, et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 Jan 27;117(4):1311-4.|[2]Chien W, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014 Jul 15;5(13):4881-94.|[3]Namba T, et al. Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway. Oncotarget. 2015 Aug 21;6(24):19990-20001.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15845/STF-083010-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15845/STF-083010-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
307543-71-1
Available Sizes
Curated Selection
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