STF-083010

STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

Product Specifications

CAS Number

[307543-71-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/STF-083010.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CS1)(/N=C/C2=C3C=CC=CC3=CC=C2O)=O

Molecular Formula

C15H11NO3S2

Molecular Weight

317.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Papandreou I, et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 Jan 27;117 (4) :1311-4.|[2]Chien W, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014 Jul 15;5 (13) :4881-94.|[3]Namba T, et al. Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway. Oncotarget. 2015 Aug 21;6 (24) :19990-20001.