H-Trp-Glu-OH
H-Trp-Glu-OH is a selective, reversible and cell-permeable PPARγ with a Kd of ~8 µM. H-Trp-Glu-OH might be developed as a possible lead compound in diabetes research[1].
Product Specifications
CAS Number
36099-95-3
Product Name Alternative
G3335
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/h-trp-glu-oh.html
Purity
99.95
Solubility
DMSO : 20.83 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(O)CC[C@@H](C(O)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O
Molecular Formula
C16H19N3O5
Molecular Weight
333.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Ye F, et al. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Chembiochem. 2006 Jan;7 (1) :74-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
Available Sizes
Frequently Asked Questions
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