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H-​Trp-​Glu-​OH

H-​Trp-​Glu-​OH is a selective, reversible and cell-permeable PPARγ with a Kd of ~8 µM. H-​Trp-​Glu-​OH might be developed as a possible lead compound in diabetes research[1].

Product Specifications

CAS Number

[36099-95-3]

Product Name Alternative

G3335

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/h-trp-glu-oh.html

Purity

99.95

Solubility

DMSO : 20.83 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(O)CC[C@@H](C(O)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O

Molecular Formula

C16H19N3O5

Molecular Weight

333.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Ye F, et al. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Chembiochem. 2006 Jan;7 (1) :74-82.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARγ

Available Sizes

Curated Selection

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