Sanguinarine (gluconate)

Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS) . Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB[1].

Product Specifications

CAS Number

[132210-34-5]

Product Name Alternative

Sanguinarin (gluconate) ; Sanguinarium (gluconate) ; Pseudochelerythrine (gluconate)

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sanguinarine-gluconate.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.C[N+]1=CC2=C3C(OCO3)=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4

Molecular Formula

C26H25NO11

Molecular Weight

527.48

References & Citations

[1]Wang Y, Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7 (16) :22355-67.