Sanguinarine (gluconate)
Product Specifications
UNSPSC Description
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB[1].
Target Antigen
Apoptosis; Reactive Oxygen Species
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sanguinarine-gluconate.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.C[N+]1=CC2=C3C(OCO3)=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4
Molecular Weight
527.48
References & Citations
[1]Wang Y, Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7(16):22355-67.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0052C/Sanguinarine-gluconate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0052C/
Clinical Information
Phase 4
CAS Number
132210-34-5
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