RAP80 Rabbit Monoclonal Antibody

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD266; TNFRSF12A; FN14

UniProt

Q96RL1

Reactivity

Human

Immunogen

A synthesized peptide derived from human RAP80 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) .

Target

BRCA1-A complex subunit RAP80

Clonality

Monoclonal

Clone

BCFEJX43

Conjugation

Unconjugated

Field of Research

Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Dilution

WB 1:500-2000 IHC 1:50-200 ICC/IF 1:50-200

Form

Liquid

Molecular Weight

70,90 kDa

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

ICC, IF, IHC, WB

Host or Source

Rabbit

Preservative

Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.