BpV (HOpic)
BpV (HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV (HOpic) has neuroprotective activity[1][2].
Product Specifications
CAS Number
722494-26-0
Product Name Alternative
Bisperoxovanadium
UNSPSC
12352005
Hazard Statement
H315, H319
Target
PTEN
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bpv-hopic.html
Purity
98.0
Solubility
DMSO : 2.89 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC(O)=CC=C4C3=O.[2K+]
Molecular Formula
C6H4K2NO8V
Molecular Weight
347.24
Precautions
H315, H319
References & Citations
[1]Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566 (1-3) : 35-8.|[2]Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17 (1) : 414-421.|[3]Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv (Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34 (2) : 125-36.|[4]Raffel N, et, al. The effect of bpV (HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54 (8) : 1057-1063.|[5]Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17 (4) : 474-82.|[6]Zhou J, et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7 (1) : 9503.|[7]Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8 (29) : 18741-53.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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