BpV (HOpic)

BpV (HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV (HOpic) has neuroprotective activity[1][2].

Product Specifications

CAS Number

[722494-26-0]

Product Name Alternative

Bisperoxovanadium

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PTEN

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bpv-hopic.html

Purity

98.0

Solubility

DMSO : 2.89 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC(O)=CC=C4C3=O.[2K+]

Molecular Formula

C6H4K2NO8V

Molecular Weight

347.24

Precautions

H315, H319

References & Citations

[1]Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566 (1-3) : 35-8.|[2]Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17 (1) : 414-421.|[3]Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv (Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34 (2) : 125-36.|[4]Raffel N, et, al. The effect of bpV (HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54 (8) : 1057-1063.|[5]Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17 (4) : 474-82.|[6]Zhou J, et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7 (1) : 9503.|[7]Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8 (29) : 18741-53.