ML-7 (hydrochloride)
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM) . ML-7 hydrochloride also inhibits YAP/TAZ.
Product Specifications
CAS Number
110448-33-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin; YAP
Type
Reference compound
Related Pathways
Cytoskeleton; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML-7-hydrochloride.html
Purity
99.88
Solubility
DMSO : ≥ 43 mg/mL|H2O : 1.43 mg/mL (ultrasonic)
Smiles
O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.Cl
Molecular Formula
C15H18ClIN2O2S
Molecular Weight
452.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Shi J, et al. Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293cells. Br J Pharmacol. 2007 Sep;152 (1) :122-31.|[2]Yu J, et al. Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci. 2015 Sep 4;12 (9) :727-36|[3]Luh C, et al. Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury. J Neurochem. 2010 Feb;112 (4) :1015-25.|[4]Pobbati AV, et, al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ
Available Sizes
Frequently Asked Questions
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