ML-7 (hydrochloride)

ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM) . ML-7 hydrochloride also inhibits YAP/TAZ.

Product Specifications

CAS Number

[110448-33-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Myosin; YAP

Type

Reference compound

Related Pathways

Cytoskeleton; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML-7-hydrochloride.html

Purity

99.88

Solubility

DMSO : ≥ 43 mg/mL|H2O : 1.43 mg/mL (ultrasonic)

Smiles

O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.Cl

Molecular Formula

C15H18ClIN2O2S

Molecular Weight

452.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Shi J, et al. Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293cells. Br J Pharmacol. 2007 Sep;152 (1) :122-31.|[2]Yu J, et al. Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci. 2015 Sep 4;12 (9) :727-36|[3]Luh C, et al. Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury. J Neurochem. 2010 Feb;112 (4) :1015-25.|[4]Pobbati AV, et, al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.