Pentachloropseudilin
Product Specifications
UNSPSC Description
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β[1][2].
Target Antigen
Myosin; TGF-β Receptor
Type
Reference compound
Related Pathways
Cytoskeleton;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pentachloropseudilin.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C2=C(Cl)C(Cl)=C(Cl)N2)C=C(Cl)C=C1Cl
Molecular Weight
331.41
References & Citations
[1]Chinthalapudi K, et al. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286(34):29700-29708.|[2]Chung CL, et al. Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells. Chembiochem. 2018;19(8):851-864. |[3]Cota Teixeira S, et al. Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle. Chembiochem. 2019;20(18):2390-2401.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115669/Pentachloropseudilin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115669/Pentachloropseudilin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
69640-38-6
Available Sizes
Curated Selection
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