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Moxidectin-d3

Moxidectin-d3 (CL-301423-d3) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk[1][2][3][4].

Product Specifications

Product Name Alternative

CL-301423-d3

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; BCRP; Isotope-Labeled Compounds; Parasite; P-glycoprotein

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

95.71

Smiles

C/C([C@H]([C@H](/C1=N/OC([2H])([2H])[2H])C)O[C@]2(C1)C[C@](OC([C@@](C=C(C)[C@@H](O)[C@@]3([H])OC/C4=C\C=C\[C@H](C)C5)([H])[C@@]34O)=O)([H])C[C@](C/C=C5\C)([H])O2)=C\C(C)C

Molecular Formula

C37H50D3NO8

Molecular Weight

642.84

Precautions

H301

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Moxidectin, From Wikipedia|[3]Kiki-Mvouaka S, et al. Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice. Drug Metab Dispos. 2010 Apr;38 (4) :573-80.|[4]Perez M, et al. In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 2009 Jun 15;180 (1) :106-12.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Badge

Hot

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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