Apostatin-1
Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1].
Product Specifications
CAS Number
[2559703-06-7]
Product Name Alternative
Apt-1
UNSPSC
12352005
Target
Apoptosis; Autophagy; Beclin1; Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apostatin-1.html
Purity
99.84
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 80°C)
Smiles
O=C(NC1CCCCCC1)C(SC2=NCCN2C)C3=CC=CC=C3
Molecular Formula
C19H27N3OS
Molecular Weight
345.50
References & Citations
[1]Xu D, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587 (7832) :133-138.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
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