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Ro 41-1049 (hydrochloride)

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A) . An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively) [1].

Product Specifications

CAS Number

127917-66-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ro-41-1049-hydrochloride.html

Purity

99.96

Solubility

DMSO : ≥ 32 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C2=CC=CC(F)=C2)SC=N1)NCCN.[H]Cl

Molecular Formula

C12H13ClFN3OS

Molecular Weight

301.77

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37 (3) :358-66.|[2]Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8 (1-2) :99-105.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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