Fludrocortisone acetate

Fludrocortisone acetate (9α-Fludrocortisone acetate) is an orally active synthetic mineralocorticoid. Fludrocortisone acetate can effectively control sodium retention. Fludrocortisone acetate is used in studies of cardiac injury, adrenal insufficiency and orthostatic hypotension[1][2][3].

Product Specifications

CAS Number

[514-36-3]

Product Name Alternative

9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Mineralocorticoid Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Fludrocortisone-acetate.html

Purity

99.59

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Molecular Formula

C23H31FO6

Molecular Weight

422.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Fitzgerald M, et al. Mineralocorticoids restore quiescent morphology and reduce VEGF receptor expression in inflamed choroidal endothelial cells in vitro. Ophthalmic Res. 2009;41 (1) :44-52.|[2]Sarker M, et al. Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway. Biomed Pharmacother. 2024 Dec;181:117703.|[3]Djajadiningrat-Laanen SC, et al. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med. 2008 Nov-Dec;22 (6) :1283-8.