Guanoxabenz (hydrochloride)
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3].
Product Specifications
CAS Number
23256-40-8
Product Name Alternative
Hydroxyguanabenz (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/guanoxabenz-hydrochloride.html
Purity
99.72
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC1=C(/C=N/NC(NO)=N)C(Cl)=CC=C1.[H]Cl
Molecular Formula
C8H9Cl3N4O
Molecular Weight
283.54
References & Citations
[1]Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmacol. 1998 Nov 1;56 (9) :1111-9.|[2]Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Biochem Pharmacol. 1998 Nov 1;56 (9) :1121-8.|[3]Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83 (4) :158-63.|[4]P W Dettmar, et al. Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Neuropharmacology. 1983 Jun;22 (6) :729-37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-G213674-25MG 25 mg
Guanosine 2’,3’-Cyclic Phosphate-13C5 Triethylammonium Salt
Sign In for Pricing
View Details 
MBS7099058 Inquire
Recombinant Human Uncharacterized membrane protein C19orf24 (C19orf24) , partial
Sign In for Pricing
View Details MBS7196993 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) PHO1-H10 Polyclonal Antibody
Sign In for Pricing
View Details