Guanoxabenz (hydrochloride)
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3].
Product Specifications
CAS Number
23256-40-8
Product Name Alternative
Hydroxyguanabenz (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/guanoxabenz-hydrochloride.html
Purity
99.72
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC1=C(/C=N/NC(NO)=N)C(Cl)=CC=C1.[H]Cl
Molecular Formula
C8H9Cl3N4O
Molecular Weight
283.54
References & Citations
[1]Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmacol. 1998 Nov 1;56 (9) :1111-9.|[2]Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Biochem Pharmacol. 1998 Nov 1;56 (9) :1121-8.|[3]Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83 (4) :158-63.|[4]P W Dettmar, et al. Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Neuropharmacology. 1983 Jun;22 (6) :729-37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
Frequently Asked Questions
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