Protein Kinase C (19-36)

Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response[1].

Product Specifications

CAS Number

[113731-96-7]

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/protein-kinase-c-19-36.html

Purity

99.14

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NC(C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](C)NC(CNC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O

Molecular Formula

C93H159N35O24

Molecular Weight

2151.48

References & Citations

[1]Yasunari K, et al. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension. 1996 Aug;28 (2) :159-68.