HMG499
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis[1].
Product Specifications
CAS Number
2416941-68-7
Product Name Alternative
AM152,AM152 (sodium)
UNSPSC
12352211
Target
Autophagy; HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/HMG499.html
Purity
96.78
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C[C@H](CCCC(CC=C)(CC=C)O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C(C)(C)[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C33H54O3
Molecular Weight
498.78
References & Citations
[1]Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9 (1) :5138.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E-UNEL-M0143-01 5x 96 Tests
Uncoated Mouse PGF (Placental Growth Factor) ELISA Kit
Sign In for Pricing
View Details E-UNEL-M0143-02 15x 96 Tests
Uncoated Mouse PGF (Placental Growth Factor) ELISA Kit
Sign In for Pricing
View Details ![Elab Fluor® Red 780 Anti-Mouse CD64/FcγRI Antibody[X54-5/7.1]](https://cdn.genprice.uk/products/763/68dd149b061270361e7cef1e/imageurl/e-ab-f1186us.webp)
E-AB-F1186US-01 25 µg
Elab Fluor® Red 780 Anti-Mouse CD64/FcγRI Antibody[X54-5/7.1]
Sign In for Pricing
View Details E-AB-F1186US-02 100 µg
Elab Fluor® Red 780 Anti-Mouse CD64/FcγRI Antibody[X54-5/7.1]
Sign In for Pricing
View Details 