PF15 (TFA)
PF15 TFA is a PROTAC connected by ligands for FLT3 kinase and CRBN. PF15 TFA is a high selective FLT3-ITD degrader, with a DC50 of 76.7 nM. PF15 TFA significantly inhibits the proliferation of FLT3-ITD-positive cells, can down-regulate the phosphorylation of FLT3 and STAT5. PF15 TFA also inhibits tumor growth in mouse models and can be used in study of leukemia[1].
Product Specifications
UNSPSC
12352005
Target
FLT3; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf15-tfa.html
Purity
99.72
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC(C)(C1=CC(NC(NC2=CC=C(C=C2)C3=CN(C4=NC=NC(N)=C34)CCCCC5=CN(N=N5)CCCCC(NC6=C7CN(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=NO1)C.O=C(O)C(F)(F)F
Molecular Formula
C46H50F3N13O8
Molecular Weight
969.97
References & Citations
[1]Chen Y, et al. Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC) . Bioorg Chem. 2022 Feb;119:105508.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Archaeoglobus fulgidus Uncharacterized protein AF_2132 (AF_2132)
Delta Sarcoglycan Rabbit Polyclonal Antibody (BF488)