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KG-501

KG-501 is a CREB inhibitor, with an IC50 of 6.89 μM.

Product Specifications

CAS Number

18228-17-6

Product Name Alternative

Naphthol AS-E phosphate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/KG-501.html

Purity

99.84

Solubility

DMSO : 6 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3

Molecular Formula

C17H13ClNO5P

Molecular Weight

377.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee JW, et al. A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS One. 2015 Apr 21;10 (4) :e0122628.|[2]Best JL et al. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A. 2004 Dec 21;101 (51) :17622-7|[3]Sun H, et al. Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila) . 2008 Oct;1 (5) :316-28.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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