KG-501
KG-501 is a CREB inhibitor, with an IC50 of 6.89 μM.
Product Specifications
CAS Number
[18228-17-6]
Product Name Alternative
Naphthol AS-E phosphate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/KG-501.html
Purity
99.84
Solubility
DMSO : 6 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3
Molecular Formula
C17H13ClNO5P
Molecular Weight
377.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee JW, et al. A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS One. 2015 Apr 21;10 (4) :e0122628.|[2]Best JL et al. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A. 2004 Dec 21;101 (51) :17622-7|[3]Sun H, et al. Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila) . 2008 Oct;1 (5) :316-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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