HLA DP/DQ/DR mAb (IVA12), InVivoPure
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs) . HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
Product Specifications
Product Name Alternative
Anti-panHLA-II, anti-panHLA II, Anti-HLA-DP/DQ/DR
Reactivity
Human
Immunogen
Animals were immunized with the Priess human B cell line
Target
HLA DP/DQ/DR
Clonality
Monoclonal
Clone
IVA12
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Concentration
≥ 1 mg/ mL
Purity
≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
Form
Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568796
Tested Applications
FC, WB
Host or Source
Mouse
Preservative
Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Isotype
M IgG1 k
Available Sizes
Frequently Asked Questions
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