PF-06454589

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].

Product Specifications

CAS Number

[1527473-30-8]

UNSPSC

12352005

Hazard Statement

H302

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-06454589.html

Purity

99.91

Solubility

DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1N=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1

Molecular Formula

C14H16N6O

Molecular Weight

284.32

Precautions

H302

References & Citations

[1]Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4- (morpholin-4-yl) -7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58 (1) :419-32.