PF-06454589
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].
Product Specifications
CAS Number
[1527473-30-8]
UNSPSC
12352005
Hazard Statement
H302
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-06454589.html
Purity
99.91
Solubility
DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1N=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
Molecular Formula
C14H16N6O
Molecular Weight
284.32
Precautions
H302
References & Citations
[1]Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4- (morpholin-4-yl) -7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58 (1) :419-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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