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Phenylbutazone-13C12

Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS) . Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID) . Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

Product Specifications

CAS Number

1325559-13-4

UNSPSC

12352005

Hazard Statement

H301-H312+H332-H315-H319-H335

Target

COX

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/phenylbutazone-13c12.html

Purity

99.90

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL|H2O : 0.67mg/mL (ultrasonic)

Smiles

O=C1N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N([13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)C(C1CCCC)=O

Molecular Formula

C7 13C12H20N2O2

Molecular Weight

320.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52 (4) :302-6.|[2]G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27 (1) :109-14.|[3]Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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