RO5256390

RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541) . RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176) -induced TNF secretion in mouse bone marrow-derived macrophages[1][2][3].

Product Specifications

CAS Number

[1043495-96-0]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Trace Amine-associated Receptor (TAAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro5256390.html

Concentration

10mM

Purity

98.75

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1

Molecular Formula

C13H18N2O

Molecular Weight

218.30

Precautions

H315, H319

References & Citations

[1]Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42 (7) :1458-1470.|[2]Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18 (5) :543-56.|[3]Barnes DA, et al. TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages. J Neuroimmune Pharmacol. 2023 Jun;18 (1-2) :100-111.