Nα, Nα-Bis (carboxymethyl) -L-lysine

Nα, Nα-Bis (carboxymethyl) -L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα, Nα-Bis (carboxymethyl) -L-lysine can be used in bitter receptors related study[1][2][3].

Product Specifications

CAS Number

[113231-05-3]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Taste Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nα-nα-bis-carboxymethyl-l-lysine.html

Purity

98.80

Solubility

DMF : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 1.82 mg/mL (ultrasonic) |H2O : 25 mg/mL

Smiles

NCCCC[C@@H](C(O)=O)N(CC(O)=O)CC(O)=O

Molecular Formula

C10H18N2O6

Molecular Weight

262.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289 (36) :25054-25066. |[2]Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426 (1-2) :129-136. |[3]Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.