5-Heptadecylresorcinol

5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity[1][2].

Product Specifications

CAS Number

[41442-57-3]

Product Name Alternative

5-n-Heptadecylresorcinol; AR-C17

UNSPSC

12352005

Hazard Statement

H319

Target

Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/5-heptadecylresorcinol.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(CCCCCCCCCCCCCCCCC)=CC(O)=C1

Molecular Formula

C23H40O2

Molecular Weight

348.56

Precautions

H319

References & Citations

[1]Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14 (6) :1033-1044. |[2]Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem Toxicol. 2014 Oct;72:1-7.