YM-230888
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin -induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808) -induced arthritic pain models[1].
Product Specifications
CAS Number
446257-23-4
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ym-230888.html
Smiles
C1(NC2CCCCCC2)=C3C(SC(CNC[C@H]4CCCO4)=C3)=NC=N1
Molecular Formula
C19H28N4OS
Molecular Weight
360.52
References & Citations
[1]Atsuyuki Kohara, et al. Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models. Eur J Pharmacol. 2007 Sep 24;571 (1) :8-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
Frequently Asked Questions
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