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Chromenone 1

Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1].

Product Specifications

CAS Number

1639929-29-5

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/chromenone-1.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(C(F)(F)F)C=C2)=C(N3N=CN=C3)OC4=CC=CC=C14

Molecular Formula

C18H10F3N3O2

Molecular Weight

357.29

References & Citations

[1]Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65 (5) :3978-3990.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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