1-Hydroxy-ibuprofen

1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1].

Product Specifications

CAS Number

[53949-53-4]

UNSPSC

12352005

Hazard Statement

H302

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-hydroxy-ibuprofen.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C(C)C1=CC=C(C(O)C(C)C)C=C1

Molecular Formula

C13H18O3

Molecular Weight

222.28

Precautions

P264-P270-P330-P501

References & Citations

[1]Yujie He, et al. Metabolism of Ibuprofen by Phragmites australis: Uptake and Phytodegradation. Environ Sci Technol. 2017 Apr 18;51 (8) :4576-4584.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.