Onatasertib

Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.

Product Specifications

CAS Number

[1228013-30-6]

Product Name Alternative

CC-223; ATG-008

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; mTOR

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CC-223.html

Concentration

10mM

Purity

99.13

Solubility

DMSO : ≥ 27 mg/mL

Smiles

O=C1CNC2=NC=C(C3=CC=C(C(C)(O)C)N=C3)N=C2N1[C@H]4CC[C@H](OC)CC4

Molecular Formula

C21H27N5O3

Molecular Weight

397.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Mortensen DS, et al. CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. Mol Cancer Ther. 2015 Jun;14 (6) :1295-305.