THIP
THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders[1][2][3].
Product Specifications
CAS Number
64603-91-4
Product Name Alternative
Gaboxadol
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/thip.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic; adjust pH to 3 with HCl) |H2O : 23.33 mg/mL (ultrasonic)
Smiles
O=C1C2=C(CNCC2)ON1
Molecular Formula
C6H8N2O2
Molecular Weight
140.14
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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