NS-062
NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model[1].
Product Specifications
CAS Number
[2226257-92-5]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ns-062.html
Smiles
FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCCCN4CCOCC4)=C(NC([C@H]5CCCN5C(C(Cl)F)=O)=O)C=C32
Molecular Formula
C28H30Cl2F2N6O4
Molecular Weight
623.48
References & Citations
[1]Shindo N, et al., Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat Chem Biol. 2019 Mar;15 (3) :250-258.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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