PR5-LL-CM01

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM) . Anti-tumor activies[1].

Product Specifications

CAS Number

[1005307-86-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pr5-ll-cm01.html

Purity

98.37

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)

Smiles

CC1=CC=C(NC2=C3C(N(C4=CC=CC=C4)N=C3)=NC(NCCN(C)C)=N2)C=C1C

Molecular Formula

C23H27N7

Molecular Weight

401.51

Precautions

H302, H315, H319

References & Citations

[1]Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8 (25) :39963-39977.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT5

Available Sizes

Curated Selection

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